Djientcheu Deugoue Franck Yvan et al. The Papers of Medical Sciences (2023);3:e001

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Djientcheu Deugoue Franck Yvan ^1,2*, Nekam Arnaud Galvani ¹, Tetang Henri ¹, Malane Nsangou Aicha El-Ramadan ¹

¹ Laboratory of Animal Physiology, University of Yaoundé I, Yaoundé, Cameroon

² Laboratory of Physiology, University of Yaoundé I, Yaoundé, Cameroon

TO CITE: Djientcheu Deugoue FY, Nekam AG, Tetang H, Malane Nsangou AER. Effects of aqueous extract of Desmodium adscendens aerial parts on insulin and glycemic reactivity and weight development in type 2 diabetic rats. The Papers of Medical Sciences 2023;3:e001.

KEYS WORDS:

Desmodium adscendens, type 2 diabetes, rat, sucrose, streptozotocin ARTICLE INFO

 Received: 25^th March 2023

 Accepted: 17^th September 2023

 Available online: 04^th November 2023

Correspondence to:

Djientcheu Deugoue FY, Email: yvandjientcheu@gmail.com

ISSN: 2663-7545

Copyright ©2020, Djientcheu Deugoue FY et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original authors and source are credited.

ABSTRACT

Background: Diabetes mellitus is a metabolic disease due to impaired insulin secretion and/or abnormalities in the action of insulin on target tissues. Many plants already demonstrated their efficacy in the treatment of this chronic disease. The present study was undertaken to evaluate the effects of the aqueous extract of Desmodium adscendens on insulin and glycemic reactivity in type 2 diabetic rats.

Methodology: Diabetes was induced by prolonged sucrose administration followed by a single injection of streptozotocin (STZ) at a dose of 40 mg/kg. Twenty-six diabetic animals were separated into four groups, receiving respectively distilled water (10 mL/kg), metformin (200 mg/kg) or aqueous extract of D. adscendens at 100 and 200 mg/kg by oral gavage during 28 consecutive days. A fifth group of 5 healthy rats received distilled water (10 mL/kg). During the experimentation, water consumption and body weight were evaluated. After 28 days of treatment oral glucose tolerance and insulin sensitivity tests were performed.

Results: Animals made diabetic by administration of sucrose and STZ showed a significant increase in the glycemia level (p < 0.001), water consumption (p < 0.001) and a non-significant reduction of weight loss compared to those of the healthy control group. Administration of the extract significantly (p < 0.001) decreased blood glucose and water intake compared to those of untreated diabetic rats. Moreover, administration of the extract at both doses significantly (p<0.001) enhanced insulin sensitivity, compared to untreated rats.

Conclusion: The results suggest that D. adscendens treatment was able to correct the increase in water intake and improve glucose metabolism.

Key words: Desmodium adscendens, type 2 diabetes; rat, sucrose, streptozotocin